Pathology · single question

A patient has red, desquamative gingiva with epithelium separating from the basal layer. Which medication is most appropriate?

  1. Chlorhexidine rinse
  2. Nystatin
  3. Acyclovir
  4. Lidex (fluocinonide 0.05%)
Show answer and explanation

Correct answer: D. Lidex (fluocinonide 0.05%)

  • A. ❌ Chlorhexidine is antiseptic — it does not treat the underlying autoimmune process.
  • B. ❌ Nystatin treats fungal infections — not autoimmune vesiculobullous diseases.
  • C. ❌ Acyclovir is antiviral — not appropriate for an immunological condition.
  • D. ✅ Correct. Separation of epithelium from basal layer with red/desquamative gingiva is characteristic of vesiculobullous autoimmune disorders (pemphigoid or pemphigus). High-potency topical corticosteroids like FLUOCINONIDE (Lidex) are the treatment of choice.

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