Pathology · single question
A patient has elevated anti-SSA (anti-Ro) antibodies documented in their chart. What is the MOST likely diagnosis?
Show answer and explanation
Correct answer: B. Sjögren's Syndrome
Anti-SSA (anti-Ro) and anti-SSB (anti-La) antibodies are the most specific serological markers for Sjögren's Syndrome. Sjögren's is an autoimmune exocrinopathy with lymphocytic infiltration of salivary and lacrimal glands causing xerostomia and xerophthalmia (sicca symptoms). Anti-SSA can also be present in lupus, but it is most specifically associated with Sjögren's in this clinical context. Rheumatoid arthritis is associated with anti-CCP and RF, not anti-SSA.