Pathology · single question

A lab test reveals a high anti-Ro (SSA) antibody titer. Most likely diagnosis?

  1. Sjögren's syndrome
  2. Rheumatoid arthritis
  3. Systemic lupus erythematosus
  4. Sarcoidosis
Show answer and explanation

Correct answer: A. Sjögren's syndrome

  • A. Correct. Anti-Ro (SSA) and anti-La (SSB) are characteristic of Sjögren's syndrome.
  • B. RA is associated with RF and anti-CCP.
  • C. SLE can have anti-SSA but is most specifically linked to anti-dsDNA / anti-Sm; with dry-eye/dry-mouth context Sjögren is best.
  • D. Sarcoidosis has elevated ACE, not anti-Ro.

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