Pharmacology · single question
Which medication is most likely to cause medication-related osteonecrosis of the jaw (MRONJ)?
Show answer and explanation
Correct answer: C. Denosumab
- A. Adalimumab (Humira) is a TNF-alpha inhibitor used for rheumatoid arthritis; it is not primarily associated with MRONJ.
- B. Omalizumab is an anti-IgE antibody used for asthma; it is not associated with MRONJ.
- C. Correct. Denosumab (a RANKL inhibitor) is strongly associated with MRONJ (medication-related osteonecrosis of the jaw), particularly when used in oncologic doses for bone metastases.
- D. Rituximab is an anti-CD20 monoclonal antibody used in lymphoma/autoimmune disease; it is not a primary cause of MRONJ.