Pharmacology · single question
A characteristic adverse effect of isoniazid (INH) is:
Show answer and explanation
Correct answer: A. Hepatotoxicity
- A. Correct. Isoniazid can cause hepatotoxicity (and peripheral neuropathy from vitamin B6 depletion, prevented with pyridoxine supplementation).
- B. Gingival hyperplasia is associated with phenytoin, calcium-channel blockers, and cyclosporine.
- C. Photosensitivity is more associated with tetracyclines/sulfonamides.
- D. Ototoxicity is associated with aminoglycosides, not isoniazid.
Note: Isoniazid also causes peripheral neuropathy via B6 (pyridoxine) depletion — co-administer pyridoxine.