Pathology · single question
A 73-year-old male with a history of leukemia, who received a stem cell transplant 4 weeks ago, presents with multiple scattered erythematous/leukoplakic ulcerations on the palate and buccal mucosa, in varying stages of healing. What is the most likely diagnosis?
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Correct answer: A. Graft-versus-host disease
Graft-versus-host disease (GVHD) occurs when transplanted immune cells (from an allogeneic stem cell transplant) attack the recipient's own tissues, commonly producing oral mucosal lesions — multiple, scattered, erythematous and leukoplakic ulcerations in varying stages of healing are a classic oral GVHD presentation, occurring in the weeks-to-months following transplant.