Pharmacology · single question
A 35-year-old with rheumatoid arthritis takes methotrexate and adalimumab (Humira). What is the mechanism of action of the biologic (Humira)?
Show answer and explanation
Correct answer: A. TNF-alpha inhibitor (blocks tumor necrosis factor)
- A. Correct. Adalimumab (Humira) is a monoclonal antibody that binds and neutralizes TNF-alpha, a key inflammatory cytokine in RA.
- B. IL-6 receptor antagonism describes tocilizumab.
- C. CD20 B-cell depletion describes rituximab.
- D. JAK inhibition describes tofacitinib/baricitinib, not adalimumab.