Pharmacology · single question

A 22-year-old patient calls at 11PM because her daughter has a toothache. Which pain medication should be prescribed?

  1. Opioids (hydrocodone/oxycodone)
  2. Aspirin only
  3. Ibuprofen 400mg + acetaminophen 325mg (combination for dental pain)
  4. No medication — tell her to wait until morning
Show answer and explanation

Correct answer: C. Ibuprofen 400mg + acetaminophen 325mg (combination for dental pain)

  • A. Opioids are not first-line for acute dental pain and carry significant addiction/misuse risk. CDC guidelines recommend non-opioid analgesics first for dental pain.
  • B. Aspirin alone is less effective than the combination regimen for acute dental pain.
  • C. Correct. The evidence-based first-line approach to acute dental pain is the combination of ibuprofen (NSAID) + acetaminophen (non-NSAID analgesic). They work via complementary mechanisms (COX inhibition + central analgesic effect) and together provide analgesia equivalent to opioids for dental pain, without addiction risk.
  • D. Failing to provide pain management for a patient in acute pain when safe options are available is inappropriate.

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