Pathology · single question

Which viral infection most closely mimics irreversible pulpitis in its prodromal stage?

  1. Herpes simplex type 1
  2. Herpes zoster (varicella-zoster reactivation)
  3. Epstein-Barr virus
  4. Coxsackievirus (herpangina)
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Correct answer: B. Herpes zoster (varicella-zoster reactivation)

  • A. HSV-1 causes primary herpetic gingivostomatitis or recurrent herpes labialis — vesicles on keratinized mucosa/vermilion, not deep pulpal-type pain.
  • B. Correct. Prodromal V2/V3 zoster produces deep, spontaneous, poorly localized odontogenic-type pain days before the vesicular rash appears — patients are frequently misdiagnosed and receive unnecessary endodontic therapy.
  • C. EBV causes infectious mononucleosis and hairy leukoplakia, not pulpitis-like pain.
  • D. Herpangina causes posterior oropharyngeal vesicles and fever, not toothache.

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