Biostatistics & Research · single question

Which study design provides the HIGHEST level of evidence for a clinical question?

  1. Systematic review / meta-analysis of randomized controlled trials
  2. Single cohort study
  3. Case-control study
  4. Expert opinion / case report
Show answer and explanation

Correct answer: A. Systematic review / meta-analysis of randomized controlled trials

  • A. Correct. A systematic review/meta-analysis of RCTs sits at the top of the evidence pyramid, synthesizing the best available controlled data.
  • B. A single cohort study is observational and ranks below systematic reviews/RCTs.
  • C. A case-control study is observational and lower in the hierarchy.
  • D. Expert opinion/case reports are the lowest level of evidence.

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