Biostatistics & Research · single question

Which study design BEST eliminates selection bias and confounding?

  1. Randomized controlled trial
  2. Cross-sectional study
  3. Case-control study
  4. Cohort study
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Correct answer: A. Randomized controlled trial

The RCT best controls bias and confounding. Randomization distributes both known and unknown confounders equally between groups.
  • A. ✅ CORRECT – Randomization in RCTs is the most effective method to control confounding and eliminate selection bias.
  • B. ❌ Cross-sectional studies have temporal ambiguity.
  • C. ❌ Case-control studies are prone to recall bias and selection bias.
  • D. ❌ Cohort studies cannot randomize; residual confounding remains.

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