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Pathology · single question

Which statement about ectodermal dysplasia is NOT true?

  1. Affected individuals commonly have hypodontia or anodontia
  2. It is inherited in a Y-linked pattern
  3. The hair is typically fine and sparse
  4. Reduced sweating (hypohidrosis) causes heat intolerance
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Correct answer: B. It is inherited in a Y-linked pattern

  • A. ❌ True. Missing and conically shaped teeth are the cardinal dental features and often prompt the diagnosis.
  • B. ✅ CORRECT — This is the FALSE statement. The classic hypohidrotic form (Christ-Siemens-Touraine) is X-LINKED RECESSIVE, which is why it presents predominantly in males and is transmitted through carrier mothers. Autosomal dominant and recessive forms also exist. There is no Y-linked form.
  • C. ❌ True. Fine, sparse hair (hypotrichosis) completes the triad with hypodontia and hypohidrosis.
  • D. ❌ True. Absent or reduced sweat glands cause hypohidrosis and dangerous hyperthermia in warm environments.

Note: Triad to remember: hypodontia + hypotrichosis + hypohidrosis. Also frontal bossing, periorbital wrinkling, saddle nose, protuberant lips.

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