Medical Emergencies · single question
Which serologic test is most specific for rheumatoid arthritis?
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Correct answer: A. Anti-cyclic citrullinated peptide (anti-CCP) antibody
Anti-CCP antibodies are highly specific for rheumatoid arthritis and aid early diagnosis; RF is sensitive but less specific.Other options: RF is nonspecific; ANA is associated with lupus; ESR is a nonspecific inflammatory marker.Key exam takeaway: Rheumatoid arthritis: anti-CCP is the most specific antibody; RF is supportive but less specific.
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