Periodontics · single question
Which pro-inflammatory cytokine is a key mediator of bone/connective-tissue destruction in periodontitis?
Show answer and explanation
Correct answer: A. Interleukin-1 beta (IL-1β)
- A. Correct. IL-1β (along with TNF-α, IL-6, PGE2, MMPs) is a principal driver of the inflammatory tissue and bone destruction in periodontitis.
- B. IL-4 is an anti-inflammatory/Th2 cytokine.
- C. IL-10 is anti-inflammatory.
- D. TGF-β is largely regulatory/anti-inflammatory and not the key destructive mediator.