Pharmacology · single question

Which oral lesion is most commonly caused by methotrexate?

  1. Oral ulcerations
  2. Oral hyperkeratosis
  3. Decreased salivary flow
  4. Gingival hyperplasia
Show answer and explanation

Correct answer: A. Oral ulcerations

  • A. Correct. Methotrexate (an antifolate) commonly causes mucositis/oral ulcerations.
  • B. Hyperkeratosis is not a typical methotrexate effect.
  • C. Xerostomia is linked to anticholinergics, not methotrexate.
  • D. Gingival hyperplasia is associated with phenytoin, cyclosporine, and calcium-channel blockers.

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