Medical Emergencies · single question

Which of the following represents the pathophysiology of Type II diabetes mellitus?

  1. Increase in cortisol production
  2. Increased cellular resistance to insulin
  3. Pancreatic tumor
  4. Autoimmune destruction of beta cells
Show answer and explanation

Correct answer: C. Pancreatic tumor

  • A. Incorrect. Autoimmune destruction of pancreatic beta cells is the pathophysiology of Type 1 DM.
  • B. Incorrect. Cortisol excess causes secondary diabetes (Cushing's syndrome), not Type 2.
  • C. Correct. Type 2 DM is characterized by peripheral insulin resistance (muscle, fat, liver cells fail to respond to insulin) combined with progressive beta cell dysfunction. Obesity is the primary driver.
  • D. Incorrect. Pancreatic tumors can destroy beta cell mass causing secondary diabetes, but this is not Type 2 DM pathophysiology.

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