Prosthodontics & Occlusion · single question
Which of the following best describes HPV-negative oropharyngeal carcinoma?
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Correct answer: C. Associated with alcohol
- A. While oropharyngeal carcinoma overall is more common in males, this is not the distinguishing feature of the HPV-negative subtype specifically (both subtypes occur more in males).
- B. HPV-positive oropharyngeal carcinoma incidence is increasing; HPV-negative disease incidence has actually been declining as tobacco use decreases.
- C. Correct. HPV-negative oropharyngeal carcinoma is classically associated with tobacco and alcohol use, unlike HPV-positive disease which occurs independent of these risk factors.
- D. HPV-negative disease has a WORSE prognosis than HPV-positive disease, not better.
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