Pharmacology · single question
Which monoclonal antibody medication is associated with medication-related osteonecrosis of the jaw (MRONJ) via RANKL inhibition?
Show answer and explanation
Correct answer: C. Denosumab
- A. Alendronate causes MRONJ but is a bisphosphonate, not a monoclonal antibody.
- B. Zoledronate is an IV bisphosphonate, not a monoclonal antibody.
- C. Correct. Denosumab is a monoclonal antibody that inhibits RANKL, suppressing osteoclasts and bone turnover — a recognized MRONJ cause.
- D. Raloxifene is a SERM used for osteoporosis and is not a classic MRONJ monoclonal.