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Periodontics · single question

Which interleukin is MOST significantly involved in periodontal disease pathogenesis?

  1. IL-4
  2. IL-12
  3. IL-10
  4. IL-1beta
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Correct answer: D. IL-1beta

IL-1beta is the key pro-inflammatory cytokine in periodontitis — stimulates osteoclast activity, bone resorption, PGE2, and MMP release. IL-10 is anti-inflammatory. IL-12 promotes Th1. IL-4 promotes Th2.

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