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Periodontics · single question

Which interleukin is involved in periodontal disease?

  1. IL-10
  2. IL-12
  3. IL-1β
  4. TNF
Show answer and explanation

Correct answer: C. IL-1β

  • A. INCORRECT. IL-10 is anti-inflammatory and downregulates the response.
  • B. INCORRECT. IL-12 mainly drives Th1 differentiation and is not the central periodontal mediator.
  • C. CORRECT. IL-1β is a key proinflammatory cytokine driving bone resorption and tissue destruction in periodontitis.
  • D. INCORRECT. TNF contributes, but among these IL-1β is the classic periodontal interleukin.

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