Pediatric Dentistry · single question
Which disease has the highest risk for developing osteosarcoma?
Show answer and explanation
Correct answer: A. Paget's disease of bone
- A. Correct. Paget's disease of bone (osteitis deformans) is associated with a significantly increased risk of OSTEOSARCOMA (also fibrosarcoma and chondrosarcoma) developing within pagetic bone. While fibrous dysplasia also has a small malignant transformation risk, Paget's disease carries the highest recognized risk.
- B. Osteoporosis is associated with fracture risk, not osteosarcoma.
- C. Fibrous dysplasia rarely undergoes malignant transformation; the risk is much lower than in Paget's disease.
- D. Hyperthyroidism causes high bone turnover and osteoporosis but is NOT associated with osteosarcoma.
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