Pediatric Dentistry · single question

Which condition is characterized by premature fusion of craniofacial sutures (craniosynostosis)?

  1. Crouzon syndrome
  2. Pierre Robin sequence
  3. Treacher Collins syndrome
  4. Down syndrome
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Correct answer: A. Crouzon syndrome

Crouzon syndrome is an autosomal dominant condition caused by mutations in the FGFR2 gene, characterized by craniosynostosis (premature fusion of cranial sutures). This results in: (1) midface hypoplasia with characteristic dish-face appearance; (2) exophthalmos (prominent eyes) due to shallow orbits; (3) hypertelorism (wide-set eyes); (4) Class III malocclusion; and (5) potential for obstructive sleep apnea. Dental manifestations include high-arched or cleft palate, crowding, and anterior open bite. Unlike Apert syndrome, Crouzon syndrome does not have digital/limb abnormalities.

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