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Pathology · single question

Which coagulation test specifically monitors the intrinsic pathway affected by Hemophilia A (Factor VIII deficiency)?

  1. Bleeding time
  2. Platelet count
  3. Partial thromboplastin time (PTT)
  4. Prothrombin time (PT/INR)
Show answer and explanation

Correct answer: C. Partial thromboplastin time (PTT)

Hemophilia A = Factor VIII deficiency. Factor VIII is part of the intrinsic pathway. PTT monitors the intrinsic pathway (XII, XI, IX, VIII, X, V, II, I). In Hemophilia A: PTT is prolonged, PT/INR is normal.
  • A. Bleeding time reflects platelet plug formation (primary hemostasis) — normal in hemophilia.
  • B. Platelet count is normal in hemophilia — it's a clotting factor deficiency, not a platelet disorder.
  • C. CORRECT. PTT monitors the intrinsic pathway. Hemophilia A causes prolonged PTT with normal PT/INR.
  • D. PT/INR monitors the EXTRINSIC pathway (Factor VII + common pathway) — normal in Hemophilia A.

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