Which cell type is primarily responsible for new bone formation after tooth extraction?

After tooth extraction, the healing sequence progresses: (1) clot formation (minutes to hours); (2) early granulation tissue with fibroblasts and capillaries (3-5 days); (3) woven bone formation by osteoblasts begins (1-2 weeks); (4) bone remodeling and maturation (months). Osteoblasts synthesize and deposit the organic matrix of bone (osteoid), which then mineralizes. They are derived from mesenchymal stem cells in the periosteum and bone marrow. Osteoclasts are needed for bone remodeling (removing woven bone and replacing with lamellar bone). Odontoblasts produce dentin (not bone). Fibroblasts produce the collagen framework for soft tissue healing.