Periodontics · single question
Which antibiotic combination is used for aggressive (generalized) periodontitis?
Show answer and explanation
Correct answer: D. Metronidazole + Amoxicillin
- A. Chlorhexidine is an antiseptic/mouth rinse, not a systemic antibiotic. This combination is not the standard for aggressive periodontitis.
- B. Metronidazole + Chlorhexidine: chlorhexidine is local/topical, not systemic — not the standard combination.
- C. Amoxicillin/clavulanate is used for some infections but is not the first-line combination specifically for aggressive periodontitis.
- D. Metronidazole + Amoxicillin (used together) is the GOLD STANDARD systemic antibiotic regimen for aggressive periodontitis. Metronidazole covers anaerobes (including A. actinomycetemcomitans), and amoxicillin broadens coverage. This combination has the strongest evidence per Socransky and AAP guidelines.