Pharmacology · single question

Which analgesic should be AVOIDED in this patient?

  1. Acetaminophen at maximum dose
  2. Ibuprofen (NSAIDs)
  3. Codeine (reduced dose)
  4. Both A and B
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Correct answer: D. Both A and B

In advanced cirrhosis, standard acetaminophen doses are hepatotoxic (a reduced ceiling of ~2 g/day is recommended, not 4 g), and NSAIDs are avoided because of impaired platelet function, risk of GI bleeding from varices, and renal impairment (hepato-renal syndrome). Low-dose acetaminophen is generally preferred over NSAIDs when needed. Of the two, ibuprofen is more universally avoided; high-dose acetaminophen also poses risk.

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