When framing a clinical question using the PICO format, what do the letters represent?

PICO structures evidence-based questions into Population/patient, Intervention, Comparison, and Outcome (e.g., fluoride as the intervention, 6-month recalls as the comparison), guiding focused literature searches.Other options: The other expansions are not the PICO framework.Key exam takeaway: PICO = Population, Intervention, Comparison, Outcome.