Biostatistics & Research · single question
What study design provides the HIGHEST level of evidence in dentistry?
Show answer and explanation
Correct answer: A. Systematic review with meta-analysis
- A. Correct. A SYSTEMATIC REVIEW WITH META-ANALYSIS is at the top of the evidence hierarchy. It systematically gathers and statistically combines results from multiple high-quality RCTs, providing the most precise and reliable estimate of an effect.
- B. Incorrect. Cohort studies are observational (Level II–III evidence) — below RCTs and systematic reviews.
- C. Incorrect. Case series represent anecdotal Level IV–V evidence with no control group.
- D. Incorrect. RCTs are excellent (Level I individual study) but a systematic review of multiple high-quality RCTs provides even stronger evidence.
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