Pharmacology · single question
What is the principal CNS mechanism of action of ethanol (alcohol)?
Show answer and explanation
Correct answer: A. Enhances GABA-A receptor activity and inhibits NMDA receptors (net CNS depression)
- A. Correct. Ethanol potentiates inhibitory GABA-A signaling and inhibits excitatory NMDA glutamate receptors, depressing neuronal activity.
- B. It does the opposite of blocking GABA/activating NMDA.
- C. Its action is broad CNS depression, not isolated nicotinic stimulation.
- D. It does not act primarily by inhibiting acetylcholinesterase.