Pathology · single question
What is the MOST common HPV-associated malignancy in the United States?
Show answer and explanation
Correct answer: D. Oropharyngeal cancer (tonsils, base of tongue)
HPV-16 is now the leading cause of oropharyngeal cancer in the U.S. (tonsils, base of tongue), surpassing tobacco-related cancers.
- A. ❌ Oral cavity SCC is more strongly associated with tobacco and alcohol than HPV.
- B. ❌ Laryngeal cancer is primarily smoking-associated.
- C. ❌ While HPV causes cervical cancer, oropharyngeal cancer has surpassed it in the USA.
- D. ✅ CORRECT – HPV-16 is the leading cause of oropharyngeal cancers in the USA.