Pharmacology · single question

What is the mechanism of action of lisinopril?

  1. Flushes out water and sodium
  2. Blocks calcium channels
  3. Inhibits vasoconstriction and decreases cardiac workload
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Correct answer: C. Inhibits vasoconstriction and decreases cardiac workload

Lisinopril is an ACE inhibitor — it prevents angiotensin II formation, causing vasodilation and reduced cardiac workload.
  • A. That describes a diuretic, not an ACE inhibitor. (Note: the recall sheet highlighted this — it is incorrect for lisinopril.)
  • B. That is the mechanism of calcium-channel blockers (e.g., amlodipine), not lisinopril.
  • C. Correct. Lisinopril is an ACE inhibitor: it blocks conversion of angiotensin I to angiotensin II, reducing vasoconstriction and afterload.

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