Pharmacology · single question

What is the mechanism of action of ibuprofen?

  1. Non-selective cyclooxygenase (COX-1/COX-2) inhibitor
  2. Selective COX-2 inhibitor
  3. Irreversible COX-1 inhibitor
  4. Lipoxygenase inhibitor
Show answer and explanation

Correct answer: A. Non-selective cyclooxygenase (COX-1/COX-2) inhibitor

  • A. Correct. Ibuprofen reversibly and non-selectively inhibits both COX-1 and COX-2, reducing prostaglandin synthesis.
  • B. Selective COX-2 inhibition describes celecoxib, not ibuprofen.
  • C. Irreversible COX inhibition describes aspirin.
  • D. Ibuprofen does not act on the lipoxygenase pathway.

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