Pharmacology · single question
What is the mechanism of action of Humira (adalimumab)?
Show answer and explanation
Correct answer: C. Specifically binds TNF-alpha and blocks its interaction with cells
- A. IL-6 receptor blockade is the mechanism of tocilizumab (Actemra), not adalimumab.
- B. DNA synthesis inhibition describes methotrexate, not adalimumab.
- C. Correct. Adalimumab (Humira) is a fully human monoclonal antibody that specifically binds TNF-alpha (tumor necrosis factor-alpha), a key inflammatory cytokine, blocking its interaction with TNF receptors and reducing inflammation.
- D. Calcineurin inhibition is the mechanism of cyclosporine and tacrolimus.