Restorative & Materials · single question
What is the mechanism of action of fluoride in caries prevention?
Show answer and explanation
Correct answer: A. Reduces the solubility of calcium phosphate (enamel)
✓ A) Reduces solubility of enamel is correct.
Fluoride replaces hydroxyl groups in hydroxyapatite to form fluorapatite (Ca₁₀(PO₄)₆F₂). Fluorapatite is significantly LESS SOLUBLE in acid than hydroxyapatite, making enamel more resistant to cariogenic acid attacks. Additionally, fluoride enhances remineralization, inhibits bacterial enzyme (enolase) activity, and reduces acidogenicity of plaque. It does not reduce the concentration of hydroxyapatite — it converts it to a more stable form.
Fluoride replaces hydroxyl groups in hydroxyapatite to form fluorapatite (Ca₁₀(PO₄)₆F₂). Fluorapatite is significantly LESS SOLUBLE in acid than hydroxyapatite, making enamel more resistant to cariogenic acid attacks. Additionally, fluoride enhances remineralization, inhibits bacterial enzyme (enolase) activity, and reduces acidogenicity of plaque. It does not reduce the concentration of hydroxyapatite — it converts it to a more stable form.
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