What is the first-line antifungal treatment for denture stomatitis caused by Candida albicans?

Nystatin is the first-line topical antifungal for oral candidiasis and denture stomatitis. It is a polyene antifungal that binds to ergosterol in the fungal cell membrane, causing increased permeability and cell death. It is poorly absorbed from the gastrointestinal tract, making it safe for local mucosal use. In addition to antifungal treatment, the patient's denture must be treated (soaked in dilute chlorhexidine or nystatin solution) because it serves as a reservoir for Candida. Systemic fluconazole is reserved for recurrent or resistant cases, or immunocompromised patients.