What is the first clinical sign of dental caries?

The earliest visible caries lesion is the white spot lesion, a chalky, opaque area of subsurface enamel demineralization that is still reversible with remineralization therapy.Other options: Cavitation, pulp exposure, and mobility are later, more advanced stages.Key exam takeaway: First sign of caries = white spot (early demineralization), which can be remineralized.