What is the causative microorganism most commonly responsible for denture stomatitis?

Denture stomatitis (also called denture-related stomatitis or chronic atrophic oral candidiasis) is the most common oral mucosal lesion associated with denture wearing. It is caused by Candida albicans, a commensal yeast that colonizes the fitting surface of dentures and the underlying palatal mucosa. Clinically, it presents as erythema (redness) and edema of the denture-bearing mucosa, typically classified using Newton's classification (Type I: localized simple inflammation; Type II: generalized simple erythema; Type III: granular/nodular type). Treatment includes antifungal therapy (nystatin or fluconazole), improved denture hygiene, and ideally removal of dentures at night.