Pathology · single question
What is the BEST non-invasive method for the diagnosis of Mucous Membrane Pemphigoid (MMP)?
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Correct answer: A. Nikolsky sign
✓ A) Nikolsky sign is noted as the answer in this context.
The Nikolsky sign (lateral pressure on apparently normal mucosa produces sloughing/blister formation) is a non-invasive clinical test used to detect epithelial fragility in MMP and pemphigus. However, clinically the gold standard for definitive diagnosis is biopsy with direct immunofluorescence showing linear IgG/C3 at the basement membrane. Nikolsky sign is the best non-invasive test mentioned in this question set.
The Nikolsky sign (lateral pressure on apparently normal mucosa produces sloughing/blister formation) is a non-invasive clinical test used to detect epithelial fragility in MMP and pemphigus. However, clinically the gold standard for definitive diagnosis is biopsy with direct immunofluorescence showing linear IgG/C3 at the basement membrane. Nikolsky sign is the best non-invasive test mentioned in this question set.