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Medical Emergencies · single question

What is NOT true about a patient with Factor V Leiden mutation?

  1. Oral contraceptives decrease clotting risk in these patients
  2. The condition is an inherited thrombophilia
  3. They have an increased risk of venous thrombosis
  4. They may require anticoagulant therapy
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Correct answer: A. Oral contraceptives decrease clotting risk in these patients

  • A. Correct — NOT true. Oral contraceptives (estrogen) INCREASE clotting risk in Factor V Leiden patients. They are generally CONTRAINDICATED or used with extreme caution because they amplify the already elevated thrombosis risk.
  • B. Incorrect — this IS true. Factor V Leiden is an autosomal dominant inherited mutation.
  • C. Incorrect — this IS true. Factor V Leiden causes hypercoagulability and increased VTE risk.
  • D. Incorrect — this IS true. Patients with prior thrombotic events are often on anticoagulants.

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