Tooth #3 has mobility grade III and will be extracted. What is the best post-operative analgesic regimen for significant pain?

Acetaminophen + ibuprofen For routine dental extractions, meta-analyses show acetaminophen + ibuprofen provides pain relief equal to or better than opioid combinations with fewer side effects. Opioids should be reserved for patients with specific contraindications to NSAIDs or uncontrolled pain despite multimodal therapy.12. Vesiculobullous & Autoimmune Disorders