Oral Surgery · single question

The primary medical treatment for multiple myeloma typically includes:

  1. Topical corticosteroids only
  2. Systemic chemotherapy plus systemic corticosteroids (with autologous stem cell transplantation when eligible)
  3. Radiation to the tongue
  4. Antifungal therapy
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Correct answer: B. Systemic chemotherapy plus systemic corticosteroids (with autologous stem cell transplantation when eligible)

Standard induction commonly uses a proteasome inhibitor (bortezomib), an immunomodulator (lenalidomide), and dexamethasone (VRd), followed by autologous stem cell transplantation in eligible patients. Bisphosphonates (zoledronate) or denosumab (RANKL inhibitor) are added for skeletal-related events, which significantly increases the risk of medication-related osteonecrosis of the jaw (MRONJ).

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