Pathology · single question
The presence of TZANCK CELLS (acantholytic cells) on a smear evidences which of the following viral infections?
Show answer and explanation
Correct answer: B. Varicella-Zoster Virus (VZV)
Tzanck cells (giant multinucleated epithelial cells / acantholytic cells) are found in herpetic infections — both HSV-1, HSV-2, and VZV. A Tzanck smear is performed by scraping the base of a vesicle. Both VZV and HSV produce Tzanck cells — VZV is the correct choice when HSV is not available.
- A. Incorrect in this context. HSV does produce Tzanck cells, but per the source, HSV was NOT among the answer choices — VZV was the correct selection available.
- B. CORRECT. VZV (chickenpox/shingles) produces Tzanck cells (multinucleated giant epithelial cells) at the base of vesicles — positive Tzanck test.
- C. Incorrect. HPV causes verrucae and papillomas — it does NOT produce Tzanck cells on smear.
- D. Incorrect. EBV causes infectious mononucleosis — it does not produce Tzanck cells in oral lesions.