Pathology · single question

The histopathology of cherubism most closely resembles which of the following?

  1. Fibroma
  2. Myxoma
  3. Brown tumor (of hyperparathyroidism)
  4. Histiocytosis
Show answer and explanation

Correct answer: C. Brown tumor (of hyperparathyroidism)

Cherubism is histologically a giant cell lesion (multinucleated giant cells in a fibrovascular stroma) that is essentially indistinguishable under the microscope from central giant cell granuloma and the brown tumor of hyperparathyroidism — diagnosis in all three requires correlating the histology with clinical/radiographic/laboratory findings, since the microscopic picture alone looks the same.

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