Pathology · single question
The biopsy technique that best establishes a diagnosis of pemphigus vulgaris is:
Show answer and explanation
Correct answer: B. Incisional (perilesional) biopsy
- A. The ulcer floor is denuded; epithelium needed for diagnosis is lost there.
- B. Correct. Perilesional/incisional tissue (with intact epithelium) is required, ideally with direct immunofluorescence.
- C. Cytology cannot show the architectural/immunofluorescence features needed.
- D. There is no fluid collection to aspirate.