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Pathology · single question

Regarding HPV-negative oropharyngeal carcinoma, which of the following statements is TRUE?

  1. More common in females
  2. Its incidence is increasing globally
  3. Has a better prognosis than HPV-positive carcinoma
  4. Strongly related to alcohol and tobacco use
Show answer and explanation

Correct answer: D. Strongly related to alcohol and tobacco use

  • A. INCORRECT — HPV-negative oropharyngeal carcinoma is predominantly found in males, with a strong male predominance.
  • B. INCORRECT — The incidence of HPV-NEGATIVE oropharyngeal cancer is actually DECLINING due to decreased smoking rates. It is HPV-POSITIVE oropharyngeal cancer whose incidence is increasing.
  • C. INCORRECT — HPV-negative carcinoma has a WORSE prognosis compared to HPV-positive carcinoma. HPV-positive tumors respond better to treatment and have significantly improved survival rates.
  • D. CORRECT — HPV-negative oropharyngeal carcinoma is the 'classic' form strongly associated with tobacco and alcohol use, consistent with traditional head and neck SCC risk factors.

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