Pemphigus vulgaris results from autoantibodies directed against which cell-to-cell junction?

Pemphigus vulgaris is caused by IgG autoantibodies against desmoglein in desmosomes, producing intraepithelial (suprabasal) acantholysis and a positive Nikolsky sign.Other options: Hemidesmosome targets characterize pemphigoid (subepithelial split); tight and gap junctions are not the target.Key exam takeaway: Pemphigus vulgaris = anti-desmosome (intraepithelial); pemphigoid = anti-hemidesmosome (subepithelial).