Pathology · single question

Patient with diffuse brown-black oral mucosal pigmentation (tongue shown). Which diagnosis is LEAST likely?

Peutz-Jeghers syndrome
Physiologic pigmentation
Glossitis
Addison's disease

Show answer and explanation

Correct answer: C. Glossitis

GLOSSITIS = tongue inflammation, NOT pigmentation. Physiologic pigmentation (racial), Peutz-Jeghers (melanotic macules), and Addison's disease (ACTH-mediated hyperpigmentation) all cause diffuse mucosal pigmentation. Glossitis is LEAST likely as a cause of the pigmentation pattern shown.

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