Pathology · single question

Patient with decreased salivary flow, decreased tear secretion, bilateral parotid enlargement. Most likely diagnosis?

Sjogren's syndrome
Systemic lupus erythematosus
Rheumatoid arthritis
Sarcoidosis

Show answer and explanation

Correct answer: A. Sjogren's syndrome

PRIMARY SJOGREN'S: lymphocytic infiltration of exocrine glands → xerostomia + xerophthalmia (keratoconjunctivitis sicca) + bilateral parotid enlargement. Lab: positive SSA (anti-Ro), SSB (anti-La). Lip biopsy: focal lymphocytic sialadenitis.

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