Oral Surgery · single question
Osteoinduction from an allograft involves all of the following growth factors EXCEPT:
Show answer and explanation
Correct answer: C. Interleukin-1β (IL-1β)
- A. Incorrect — BMP IS involved. BMPs are the primary mediators of OSTEOINDUCTION — they stimulate undifferentiated mesenchymal cells to differentiate into osteoblasts. Demineralized bone matrix (DBM) in allografts releases BMPs to induce new bone formation.
- B. Incorrect — PDGF IS involved. PDGF is a chemotactic and mitogenic factor for cells involved in bone healing.
- C. Correct — IL-1β is the EXCEPTION. IL-1β is a pro-inflammatory cytokine — it is primarily involved in INFLAMMATORY BONE RESORPTION (stimulates osteoclasts), not osteoinduction. It is released during inflammation and actually impedes bone formation rather than promoting it.
- D. Incorrect — TGF-β IS involved. TGF-β stimulates osteoblast proliferation and differentiation, and enhances collagen matrix deposition.