Anatomy & Histology · single question
Neuropsychiatric complications (depression, suicidal ideation) are most associated with which smoking cessation medication?
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Correct answer: C. Bupropion (Zyban/Wellbutrin) — black box warning for neuropsychiatric events
✓ C) Bupropion carries the black box warning for neuropsychiatric complications.
Bupropion (Zyban): dopamine/norepinephrine reuptake inhibitor used for smoking cessation and depression. BLACK BOX WARNING: serious neuropsychiatric events including depression, suicidal ideation, suicide attempts, and completed suicide — especially in young patients. Must monitor closely. Also lowers seizure threshold (contraindicated in seizure disorder). Varenicline also had similar warnings but they were modified. Nicotine replacement therapy (patch, gum, spray) has no significant psychiatric side effects. Dental relevance: bupropion can cause xerostomia.
Bupropion (Zyban): dopamine/norepinephrine reuptake inhibitor used for smoking cessation and depression. BLACK BOX WARNING: serious neuropsychiatric events including depression, suicidal ideation, suicide attempts, and completed suicide — especially in young patients. Must monitor closely. Also lowers seizure threshold (contraindicated in seizure disorder). Varenicline also had similar warnings but they were modified. Nicotine replacement therapy (patch, gum, spray) has no significant psychiatric side effects. Dental relevance: bupropion can cause xerostomia.
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